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Early cleavage, understood as the first embryo mitosis at 25–27 hours after insemination, has been considered to be an embryo quality parameter (1–9).


Over the past decade, numerous studies have associated its presence with embryonic morphology on days 2 and 3 (1–4), development until the blastocyst stage (5), chromosome anomalies (6), embryo viability (7–9), implantation rate (2, 10), and abortion rate (11).

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